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Usage of opioid analgesics for an extended length of time all through pregnancy could lead to neonatal opioid withdrawal syndrome [see WARNINGS AND Safety measures]. There isn't any available facts with DILAUDID INJECTION in pregnant Gals to inform a drug-associated chance for significant start defects and miscarriage or adverse maternal outcomes.

DILAUDID INJECTION is contraindicated in sufferers with known or suspected gastrointestinal obstruction, which include paralytic ileus.

If the choice is made to prescribe a benzodiazepine or other CNS depressant concomitantly having an opioid analgesic, prescribe the bottom successful dosages and minimum durations of concomitant use. In clients already acquiring an opioid analgesic, prescribe a lessen First dose on the benzodiazepine or other CNS depressant than indicated while in the absence of an opioid, and titrate dependant on medical reaction.

Inform your physician When you are Expecting or prepare to become Expecting. If you utilize hydromorphone injection regularly through your pregnancy, your infant may well encounter existence-threatening withdrawal symptoms immediately after beginning.

Disclaimer: The knowledge delivered on this webpage isn't a substitute for Qualified medical tips, prognosis, or remedy. Should you have any concerns or considerations about your health and fitness, please talk to a doctor.

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5.3 Neonatal Opioid Withdrawal Syndrome Extended utilization of DILAUDID INJECTION throughout pregnancy may lead to withdrawal in the neonate. Neonatal opioid withdrawal syndrome, contrary to opioid withdrawal syndrome in Older people, may very well be life-threatening if not recognized and taken care of, and involves management Based on protocols created by neonatology professionals.

five.1 Dependancy, Abuse, and Misuse DILAUDID INJECTION has hydromorphone, a Plan II controlled material. As an opioid, DILAUDID INJECTION exposes people on the dangers of dependancy, abuse, and misuse [see Drug Abuse and Dependence (9)]. Even though the danger of dependancy in almost any unique is unfamiliar, it could come about in individuals correctly prescribed DILAUDID INJECTION. Habit can occur at advisable dosages and In the event the drug is misused or abused. Assess Each individual affected person's threat for opioid addiction, abuse, or misuse previous to prescribing DILAUDID INJECTION and keep an eye on all individuals acquiring DILAUDID INJECTION for the event of those behaviors and problems. Threats are amplified in clients with a personal or family record of compound abuse (like drug or Alcoholic beverages abuse or habit) or psychological illness (e.

Hydromorphone was favourable within the mouse lymphoma assay inside the presence of metabolic activation, but was adverse from the mouse lymphoma assay while in the absence of metabolic activation.

There is a increased hazard that you will overuse hydromorphone When you've got or have at any time experienced any of such situations. Talk with your health treatment provider instantly and ask for guidance if you think that that you've an opioid habit or phone the U.S. Substance Abuse and Mental Health Providers Administration (SAMHSA) National Helpline at 1-800-662-Assist.

DILAUDID INJECTION may perhaps trigger significant hypotension which include orthostatic hypotension and syncope in ambulatory clients. There exists increased possibility in people whose capacity to keep up blood pressure has by now been compromised by a diminished blood quantity or concurrent administration of specified CNS depressant medicine (e.

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Know the get more info medicines you take. Retain a listing of them to show to your Health care company and pharmacist if you receive a new medication.

The pharmacokinetics of hydromorphone in sufferers with intense hepatic impairment hasn't been examined. An additional boost in Cmax and AUC of hydromorphone On this group is anticipated and may be taken into consideration when selecting a starting off dose [see CLINICAL PHARMACOLOGY].